![]() ![]() Median progression-free survival (PFS) was 5.9 months (3.48–8.28). Patients with high nuclear expression of YY1 were likely to be non-smokers (61.9 vs 40.5 %). ![]() The nuclear expression of RARβ was associated with the nuclear expression of YY1 (R2 = 0.28 p value < 0.0001). The mean and standard deviation of the nuclear expression of RARα, RARβ and YY1 were 184.5 ± 124.4, 18 ± 27 and 16.6 ± 20.5, respectively. The expression of RARα, RARβ and YY1 was assessed by immunohistochemistry and quantitative computerized image software.Įighty-five patients treated with platinum-based chemotherapy were included in the analysis. The aim of this study was to analyze the expression of RARα, RARβ and YY1 and their relationship with prognosis in patients with advanced NSCLC. In particular, a lack of RARβ expression is associated with NSCLC development. ![]() Transcription factors such as retinoic acid receptor alpha (RARα) and beta (RARβ) and Yin Yang 1 (YY1) are associated with the progression of non-small cell lung cancer (NSCLC). ![]()
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